CJC-1295 DAC

CJC-1295 DAC by Dragon Pharma

CJC-1295 DAC is Dragon Pharma's formulation of the long-acting GHRH analogue CJC-1295 with Drug Affinity Complex (DAC) at 5mg per vial. The DAC modification extends the compound's half-life from approximately 30 minutes (without DAC) to roughly 6-8 days — transforming a short-acting peptide into a long-acting sustained-release compound requiring only once or twice weekly dosing.

Also searched as: CJC-1295 DAC 5mg, long-acting GHRH, CJC 1295 with DAC, CJC-1295 Dragon Pharma.

What Does DAC Mean — The Drug Affinity Complex Explained

DAC (Drug Affinity Complex) is a chemical modification added to the CJC-1295 peptide chain that enables it to reversibly bind to albumin — the most abundant protein in blood plasma. This albumin binding is the mechanism behind the dramatically extended half-life:

• Without DAC: CJC-1295 is rapidly degraded by DPP-IV (dipeptidyl peptidase IV) enzyme in the bloodstream, resulting in a ~30-minute half-life
• With DAC: the albumin binding protects the peptide from DPP-IV degradation — the molecule dissociates from albumin, acts on GHRH receptors, then re-binds albumin, cycling in and out of active form
• The result is a ~6-8 day effective half-life from a single injection, with the compound gradually releasing from its albumin reservoir over the week
• This albumin-binding mechanism is the same principle used in several pharmaceutical drugs (including semaglutide/Ozempic) to extend peptide half-life

GH Bleed — What It Is and Why It's Debated

CJC-1295 DAC's sustained action produces what's called a "GH bleed" — a continuous, low-level GH elevation maintained throughout the week rather than discrete pulses. This differs fundamentally from both natural GH secretion and the pulsatile pattern produced by CJC-1295 no DAC + Ipamorelin:

• Natural GH pattern: 5-9 discrete pulses per day, largest during slow-wave sleep, near-zero between pulses
• CJC-1295 no DAC + Ipamorelin pattern: amplified discrete pulses, closely mimicking natural pulsatility
• CJC-1295 DAC pattern: sustained low-level elevation throughout the week with blunted pulse amplitude

The GH bleed pattern has practical advantages (convenience, consistent IGF-1 elevation) but also potential concerns: some research suggests sustained non-pulsatile GH elevation may increase insulin resistance more than pulsatile GH, and the loss of the natural pulsatile pattern is a consideration for users prioritising sleep quality and circadian alignment.

Effects and Benefits

• Sustained GH and IGF-1 elevation throughout the week from a single injection
• Minimal injection burden — once or twice weekly dosing
• Consistent, predictable GH elevation without the timing demands of short-acting peptides
• Body recomposition support through elevated GH and downstream IGF-1
• No suppression of natural testosterone — does not require Post Cycle Therapy

Dosage and Administration

At 5mg per vial, a single vial provides 2-5 weekly injections depending on dose. Unlike short-acting peptides, CJC-1295 DAC does not require timing relative to meals — because of its sustained-release mechanism, the compound maintains active levels regardless of insulin fluctuations during the day. This is a practical convenience advantage over short-acting GHRH peptides that must be dosed fasted.