Enclomiphene Citrate

Enclomiphene Citrate by Dragon Pharma

Enclomiphene Citrate is Dragon Pharma's formulation of the trans-isomer of clomiphene at 25mcg per tablet — a selective estrogen receptor modulator (SERM) used for testosterone recovery, PCT support and as a potential alternative to exogenous testosterone in hypogonadal men. Supplied in a 100-tablet pack, Enclomiphene's significance lies in what distinguishes it from Clomid: it is the active testosterone-stimulating component of Clomiphene without the visual side effects associated with the other isomer.

Also searched as: Enclomiphene 25mcg, Enclomiphene Citrate PCT, trans-clomiphene, Enclomiphene Dragon Pharma.

Clomid Is Two Compounds — The Critical Distinction

This is one of the most important and least-explained facts in PCT literature, and a genuine information gap in virtually all competitor content:

• Clomiphene Citrate (Clomid) is not a single compound — it is a racemic mixture of two geometric isomers in approximately equal proportions: Enclomiphene (trans-isomer, ~38%) and Zuclomiphene (cis-isomer, ~62%)
• Enclomiphene is the active testosterone-stimulating isomer — it blocks estrogen receptors in the hypothalamus, removing estrogen's negative feedback on LH/FSH secretion, which drives the increase in testosterone production
• Zuclomiphene has a much longer half-life (~30 days vs ~10 hours for Enclomiphene) and acts as a partial estrogen agonist — it accumulates with repeated dosing and is responsible for the visual disturbances (blurred vision, light sensitivity, floaters) commonly reported with Clomid
• Clinical pharmacology data: in a randomised crossover study, Enclomiphene alone produced equivalent testosterone elevation to the full Clomid mixture at equivalent molar doses, with significantly fewer visual side effects

Enclomiphene vs Clomid vs Nolvadex — The Three-Way Comparison

Enclomiphene as a TRT Alternative — The Emerging Application

An important and underreported application of Enclomiphene that separates it from both Clomid and Nolvadex:

• Unlike exogenous testosterone (TRT), Enclomiphene stimulates endogenous testosterone production through the HPG axis — preserving testicular function and fertility
• Phase II and III clinical trials investigated Enclomiphene specifically as a treatment for secondary hypogonadism in men who want to maintain fertility — an application where conventional TRT is contraindicated because exogenous testosterone suppresses sperm production
• Trial data demonstrated Enclomiphene at 12.5-25mg/day produced testosterone elevations to eugonadal range while maintaining or improving sperm parameters — in contrast to TRT, which consistently suppresses spermatogenesis
• This positions Enclomiphene as a clinically meaningful option for hypogonadal men whose primary concern is fertility preservation alongside testosterone restoration

Effects and Benefits

• Stimulates LH and FSH release from the pituitary, driving natural testosterone production
• Produces comparable testosterone elevation to Clomid without the zuclomiphene-related visual side effects
• Preserves testicular function and spermatogenesis — relevant for fertility-concerned users post-cycle
• Shorter half-life than zuclomiphene means faster system clearance when stopping
• Potential TRT alternative in secondary hypogonadism where fertility preservation is a priority

Dosage and Administration

At 25mcg per tablet, dosing can be adjusted by tablet splitting for the 12.5mcg dose often used as a starting point. Note: the dosing of Enclomiphene is typically lower than equivalent Clomid doses because Enclomiphene is the pure active isomer — a 25mg Clomid dose contains only ~9.5mg of Enclomiphene, meaning 25mcg of pure Enclomiphene is roughly equivalent to 65mg of Clomid on a molar basis.